Your browser doesn't support javascript.
loading
Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
J Med Chem ; 45(23): 4961-74, 2002 Nov 07.
Article em En | MEDLINE | ID: mdl-12408707
A series of novel compounds have been designed that are potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1), and the activity and physical properties have been characterized. The new structural classes, 3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-6-ones and 3,4-dihydropyrrolo[4,3,2-de]isoquinolin-5-(1H)-ones, have conformationally locked benzamide cores that specifically interact with the PARP-1 protein. The compounds have been evaluated with in vitro cellular assays that measure the ability of the PARP-1 inhibitors to enhance the effect of cytotoxic agents against cancer cell lines.
Assuntos
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dacarbazina / Inibidores Enzimáticos / Inibidores de Poli(ADP-Ribose) Polimerases / Indóis / Isoquinolinas / Antineoplásicos Limite: Humans Idioma: En Revista: J Med Chem Ano de publicação: 2002 Tipo de documento: Article
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dacarbazina / Inibidores Enzimáticos / Inibidores de Poli(ADP-Ribose) Polimerases / Indóis / Isoquinolinas / Antineoplásicos Limite: Humans Idioma: En Revista: J Med Chem Ano de publicação: 2002 Tipo de documento: Article