Long-term follow-up of patients with aplastic anemia and refractory anemia responding to combination therapy with recombinant human granulocyte colony-stimulating factor and erythropoietin.
Int J Hematol
; 76(3): 244-50, 2002 Oct.
Article
em En
| MEDLINE
| ID: mdl-12416735
ABSTRACT
In our previous study, approximately 60% of aplastic anemia (AA) and refractory anemia (RA) patients treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF) and recombinant human erythropoietin (rhEpo) showed a multilineage response. In this study, we analyzed the long-term follow-up of the multilineage responders (multi-R). In the follow-up analysis of 11 multi-R (6 AA and 5 RA), 10 patients (5 AA and 5 RA) were evaluable. The range of time from the start of treatment to the final contact was 50 to 125 months. Analysis of survival times revealed a significant difference between multi-R and non-multi-R among AA patients given this treatment (P = .016). One AA and 1 RA patient among the multi-R developed acute leukemia. Of 7 living multi-R, 3 AA and 2 RA patients did not need transfusion at final contact. Four of them maintained the target hemoglobin concentration of more than 11 g/dL for quality-of-life benefit. The findings suggested that this result is an important advantage of this treatment.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anemia Refratária
/
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Eritropoetina
/
Anemia Aplástica
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Aspecto:
Patient_preference
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Int J Hematol
Ano de publicação:
2002
Tipo de documento:
Article