Maximizing extraction of botulinum toxin type A from vials.
Arch Phys Med Rehabil
; 83(11): 1638-40, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12422338
ABSTRACT
OBJECTIVES:
To determine the residual botulinum toxin remaining in vials after using 3 different extraction methods and to analyze the different techniques for measuring extraction efficacy.DESIGN:
Multicentered comparative study.SETTING:
Three academic movement disorder clinics.PARTICIPANTS:
Thirty physicians were randomly surveyed for their botulinum toxin extraction methods. Three physicians evaluated the most common methods.INTERVENTIONS:
Not applicable. MAIN OUTCOMEMEASURE:
Amount of toxin left in vials after each extraction method.RESULTS:
Toxin was least successfully extracted by using the vial inversion method. More toxin was extracted by using the 2-in needle method. The top removal method produced the least waste of toxin but is considered unsafe.CONCLUSIONS:
The best and safest method for consistently extracting the most botulinum toxin from its vial was to use a long 21-gauge 2-in needle attached to a 3-mL syringe.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sucção
/
Toxinas Botulínicas Tipo A
/
Embalagem de Medicamentos
/
Injeções Intramusculares
/
Fármacos Neuromusculares
Tipo de estudo:
Evaluation_studies
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Revista:
Arch Phys Med Rehabil
Ano de publicação:
2002
Tipo de documento:
Article