Copper(I) hydride-catalyzed asymmetric hydrosilylation of heteroaromatic ketones.

ABSTRACT

In situ generation of CuH ligated by Takasago's new nonracemic ligand, DTBM-SEGPHOS, leads to an especially reactive reagent capable of effecting asymmetric hydrosilylation of heteroaromatic (H) ketones under very mild conditions. PMHS serves as an inexpensive source of hydride. Substrate-to-ligand ratios on the order of 20001 are employed. [reaction see text]