Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children.
Vaccine
; 21(1-2): 138-45, 2002 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-12443672
ABSTRACT
Serum responses to oral cholera vaccines were assessed in three paediatric vaccine trials, two in León, Nicaragua and one in Stockholm, Sweden. A calibrated anti-cholera toxin B subunit (CTB) IgA ELISA was used together with an assay for vibriocidal antibodies. Swedish children had lower pre-vaccination levels of antibody, but serum responses were more pronounced in Swedish children than in Nicaraguan children. Post-vaccination levels of anti-toxin antibody were generally above those found after natural infections with enterotoxigenic Escherichia coli, that cross-reacts serologically with Vibrio cholerae. Adverse events seen after vaccination were generally mild and of little clinical significance.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Vibrio cholerae
/
Vacinas contra Cólera
/
Vacinas de Produtos Inativados
/
Vacinação
/
Anticorpos Antibacterianos
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
País/Região como assunto:
America central
/
Europa
/
Nicaragua
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2002
Tipo de documento:
Article