Complete remission of Bomirski Ab amelanotic melanoma in hamsters treated with the angiogenesis inhibitor TNP-470.
Neoplasma
; 49(5): 319-22, 2002.
Article
em En
| MEDLINE
| ID: mdl-12458330
ABSTRACT
The growth of solid tumors and their metastasis is dependent on the development of new blood vessels (angiogenesis). In our previous studies it was found that angiogenesis inhibitor TNP-470 acting systematically can decrease the rate of growth of transplantable Bomirski Abmelanoma in hamsters. In this study we applied TNP-470 (30 mg/kg) peritumorally from the day when tumor was palpable over 10 days, once daily. Animals were killed 6 months later and examination by autopsy and histological preparations showed the complete remission of transplanted tumor and the lack of metastasis. Thus, Ab melanoma can be effectively cured with TNP-470 angiogenesis inhibitor when the substance is applied locally.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Melanoma Amelanótico
/
Inibidores da Angiogênese
/
Neovascularização Patológica
Limite:
Animals
Idioma:
En
Revista:
Neoplasma
Ano de publicação:
2002
Tipo de documento:
Article