Melanoma uptake of (99m)Tc complexes containing the N-(2-diethylaminoethyl)benzamide structural element.
J Med Chem
; 45(26): 5802-5, 2002 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-12477363
ABSTRACT
On the basis of the avid uptake of radioiodinated benzamides by melanoma cells, (99m)Tc complexes containing the structural elements of N-(dialkylaminoalkyl)benzamide pharmacophores have been synthesized and evaluated in vitro and in vivo for melanoma uptake. One of the complexes Tc-12 containing the ligand 4-(S-benzoyl-2-thioacetyl-glycyl-glycylamido)-N-(2-diethylaminoethyl)benzamide (11) displayed the highest melanoma uptake. The 1-h melanoma uptake values and the corresponding blood counts indicate an interdependence of tumor uptake and bioavailability of the (99m)Tc complexes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Benzamidas
/
Compostos de Organotecnécio
/
Compostos Radiofarmacêuticos
/
Dipeptídeos
/
Melanoma
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2002
Tipo de documento:
Article