Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas.
Lung Cancer
; 39(3): 273-7, 2003 Mar.
Article
em En
| MEDLINE
| ID: mdl-12609565
ABSTRACT
In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25-p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P=0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 3
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Análise Mutacional de DNA
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Genes Supressores de Tumor
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Carcinoma Pulmonar de Células não Pequenas
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Perda de Heterozigosidade
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Proteínas Supressoras de Tumor
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Ubiquitina-Proteína Ligases
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Ligases
Limite:
Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Lung Cancer
Ano de publicação:
2003
Tipo de documento:
Article