Synthesis and biological evaluation of non-peptidic cyclophilin ligands.
J Med Chem
; 46(7): 1112-5, 2003 Mar 27.
Article
em En
| MEDLINE
| ID: mdl-12646018
ABSTRACT
Peptidylprolyl isomerase cyclophilins play critical roles in a variety of biological processes. Recent findings that cyclophilins are present at high levels in the CNS and that cyclosporin A may possess neuroprotective/neurotrophic effects have prompted us to search for nonimmunosuppressant small molecule cyclophilin ligands. To this end, we report the lead identification through "virtual screening" and the synthesis of our first series of non-peptidic cyclophilin ligands, along with the preliminary biological results.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Fármacos Neuroprotetores
/
Ciclofilina A
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Med Chem
Ano de publicação:
2003
Tipo de documento:
Article