P38 mitogen-activated protein kinase influence on the production of IL-10 in human schistosomiasis mansoni.
Parasite Immunol
; 24(9-10): 493-7, 2002.
Article
em En
| MEDLINE
| ID: mdl-12654092
ABSTRACT
Schistosomiasis mansoni remains a significant public health problem in many parts of the tropics and subtropics. Clinical manifestations range from the asymptomatic intestinal form through to the hepatosplenic form of the disease, a potentially lethal clinical condition in a subsection of the exposed population. In this study, we investigated the mechanisms by which interleukin (IL)-10 production could be differentially controlled in patients with the intestinal and hepatosplenic forms of the disease, as IL-10 may play a fundamental role in the development of the hepatosplenic disease state. It is reported that p38 mitogen-activated protein (MAP) kinase signalling, and in particular p38 MAPK activation, is central to IL-10 production of cells from patients with schistosomiasis. Furthermore, the difference in the levels of activated p38 MAPK and the activation transcription factor (ATF-2), may explain the difference in the amount of IL-10 produced by cells from intestinal and hepatosplenic patients. We suggest that the type of immune response triggered in patients with hepatosplenomegaly could be influenced by the levels of phosphorylated p38 MAPK.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
/
3_ND
Base de dados:
MEDLINE
Assunto principal:
Esquistossomose mansoni
/
Interleucina-10
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Proteínas Quinases Ativadas por Mitógeno
Limite:
Adult
/
Animals
/
Humans
/
Middle aged
Idioma:
En
Revista:
Parasite Immunol
Ano de publicação:
2002
Tipo de documento:
Article