New analogues of oxotremorine and oxotremorine-M: estimation of their in vitro affinity and efficacy at muscarinic receptor subtypes.
Life Sci
; 67(6): 717-23, 2000 Jun 30.
Article
em En
| MEDLINE
| ID: mdl-12659177
ABSTRACT
Two subsets of tertiary amines (1a-6a) and methiodides (1b-6b) with a structural resemblance to oxotremorine and oxotremorine-M were tested at rabbit vas deferens (M1), guinea pig left atrium (M2), guinea pig ileum and urinary bladder (M3) muscarinic receptor subtypes. The pharmacological profile of the derivatives under study has been discussed by evaluating their potency, affinity and efficacy as well as the regional differences in muscarinic receptor occupancy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxotremorina
/
Receptores Muscarínicos
/
Agonistas Muscarínicos
Limite:
Animals
Idioma:
En
Revista:
Life Sci
Ano de publicação:
2000
Tipo de documento:
Article