188Re-labeled hydroxyapatite particles for radiation synovectomy.
Appl Radiat Isot
; 58(4): 463-8, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12672625
ABSTRACT
A new procedure for labeling hydroxyapatite (HA) particles with 188Re for radiation synovectomy is described and standardized. The particles were labeled with 188Re in high yields (99%) in acidic medium. HA particle size remained unaffected by reaction conditions as checked by laser diffraction particle analyzer. 188Re-HA was found to be stable retaining 99% radiochemical purity after 4 days when stored in ascorbic acid solution (10mg/ml, pH 5). Intra-articular injection in rats revealed approximately 98% retention of 188Re-HA in the knee after 48-h pi.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteção Radiológica
/
Radioisótopos
/
Rênio
/
Sinovectomia
/
Hidroxiapatitas
Limite:
Animals
Idioma:
En
Revista:
Appl Radiat Isot
Ano de publicação:
2003
Tipo de documento:
Article