Resistin: molecular history and prognosis.
J Mol Med (Berl)
; 81(4): 218-26, 2003 Apr.
Article
em En
| MEDLINE
| ID: mdl-12700889
ABSTRACT
Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Hormônios Ectópicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Mol Med (Berl)
Ano de publicação:
2003
Tipo de documento:
Article