[Chromogenic substrate as antidote against the thrombin inhibitor Melagatran?]. / Chromogenes Substrat als Antidot gegen den Thrombininhibitor Melagatran?
Hamostaseologie
; 23(2): 97-8, 2003 May.
Article
em De
| MEDLINE
| ID: mdl-12736706
ABSTRACT
It could be shown in vitro that a chromogenic substrate (Chromozym TH, Roche Mannheim) acts at least partially as antidote against the new thrombin inhibitor Melagatran (AstraZeneca, Mölndal, Sweden). It is discussed that this antidote effect of a chromogenic substrate might be due to a substrate competition of fibrinogen, thrombin inhibitor, and chromogenic substrate for thrombin. Further animal experiments will clarify whether this in vitro observation is of practical relevance in vivo, too.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Antitrombinas
/
Compostos Cromogênicos
/
Glicina
/
Antídotos
Limite:
Humans
Idioma:
De
Revista:
Hamostaseologie
Ano de publicação:
2003
Tipo de documento:
Article