Vaccine-induced protection against Helicobacter pylori in mice lacking both antibodies and interleukin-4.
Infect Immun
; 71(6): 3628-33, 2003 Jun.
Article
em En
| MEDLINE
| ID: mdl-12761151
ABSTRACT
To test the hypothesis that a Th2 response to Helicobacter pylori is necessary for protection and to address the possibility that humoral and Th2 cellular responses may compensate for each other, we generated mice deficient in both interleukin-4 (IL-4) and antibodies. The immunized double-knockout mice were protected from H. pylori challenge, as were the parental strains and wild-type C57BL/6 mice. Neutralization of IL-4 in B-cell-deficient mice did not prevent protection. Immunized IL-5-deficient mice were also protected. Thus, IL-4 and IL-5 are not essential for protection.
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Vacinas Bacterianas
/
Helicobacter pylori
/
Interleucina-4
/
Células Th2
/
Anticorpos Antibacterianos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
2003
Tipo de documento:
Article