Therapeutic effectiveness of novel 5-fluorouracil-loaded poly(methylidene malonate 2.1.2)-based microspheres on F98 glioma-bearing rats.
Cancer
; 97(11): 2822-9, 2003 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-12767096
ABSTRACT
BACKGROUND:
Drug delivery to the central nervous system (CNS) remains a real challenge for neurosurgeons and neurologists, because many molecules cannot cross the blood-brain barrier (BBB). In recent years, solid polymeric materials have been implanted into animal and human brains either by surgery or using stereotactic methods to assure the controlled release of a drug over a determined period, thus circumventing the difficulties posed by the BBB. Poly(methylidene malonate 2.1.2) (PMM 2.1.2) is a new polymer that was described a few years ago and that allows the fabrication of novel, 5-fluorouracil (5-FU)-loaded PMM 2.1.2 microspheres. The objective of the current study was to assess the therapeutic effectiveness of those particles in a rat brain tumor model, the F98 glioma.METHODS:
Forty-three rats were used in this study. First, a histologic evaluation of the F98 tumor model was performed on Fischer female rats. Thereafter, different groups of rats were injected and were treated with 5-FU microspheres in 2 different suspension media carboxymethylcellulose (CMC) aqueous solution with or without 5-FU.RESULTS:
The tumor was confirmed as extremely aggressive and invasive, even in early development. The 5-FU-loaded microspheres improved rat median survival significantly compared with untreated animals, CMC-treated animals, and 5-FU solution-treated animals when injected in CMC without 5-FU, demonstrating the interest of a sustained release and the efficacy of intratumoral chemotherapy against an established tumor.CONCLUSIONS:
PMM 2.1.2 microspheres appeared to be a promising system, because their degradation rate in vivo was longer compared with many polymers, and they may be capable of long-term delivery.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenos
/
Neoplasias Encefálicas
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Sistemas de Liberação de Medicamentos
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Fluoruracila
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Glioma
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Malonatos
Limite:
Animals
Idioma:
En
Revista:
Cancer
Ano de publicação:
2003
Tipo de documento:
Article