A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.

Sheehan, Scott M; Masters, John J; Wiley, Michael R; Young, Stephen C; Liebeschuetz, John W; Jones, Stuart D; Murray, Christopher W; Franciskovich, Jeffrey B; Engel, David B; Weber, Wayne W; Marimuthu, Jothirajah; Kyle, Jeffrey A; Smallwood, Jeffrey K; Farmen, Mark W; Smith, Gerald F

Sheehan, Scott M; Masters, John J; Wiley, Michael R; Young, Stephen C; Liebeschuetz, John W; Jones, Stuart D; Murray, Christopher W; Franciskovich, Jeffrey B; Engel, David B; Weber, Wayne W; Marimuthu, Jothirajah; Kyle, Jeffrey A; Smallwood, Jeffrey K; Farmen, Mark W; Smith, Gerald F.

Afiliação

Sheehan SM; Lilly Research Laboratories, A Division of Eli Lilly and Company, IN 46285, Indianapolis, USA. sheehan_scott@lilly.com

Bioorg Med Chem Lett ; 13(14): 2255-9, 2003 Jul 21.

Article em En | MEDLINE | ID: mdl-12824013

ABSTRACT

ABSTRACT

A novel isonitrile derivative was synthesized and used in an Ugi four component coupling reaction to explore aryl group substitution effects on inhibition of the coagulation cascade serine protease factor Xa.

Assuntos

Inibidores do Fator Xa; Glicina/análogos & derivados; Glicina/síntese química; Glicina/farmacologia; Inibidores de Serina Proteinase/síntese química; Inibidores de Serina Proteinase/farmacologia; Indicadores e Reagentes; Relação Estrutura-Atividade

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Serina Proteinase / Inibidores do Fator Xa / Glicina Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2003 Tipo de documento: Article

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