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The proteins of the Hepatitis C virus: their features and interactions with intracellular protein phosphorylation.
Schulze zur Wiesch, J; Schmitz, H; Borowski, E; Borowski, P.
Afiliação
  • Schulze zur Wiesch J; Partners AIDS Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.
Arch Virol ; 148(7): 1247-67, 2003 Jul.
Article em En | MEDLINE | ID: mdl-12827459
Chronic infection with Hepatitis C virus (HCV) often results in cirrhosis and enhances the probability of developing hepatocellular carcinoma (HCC). The underlying mechanisms that lead to malignant transformation of infected cells, however, remain unclear. Observations made with isolated HCV antigens and/or with HCV subgenomic replicon systems demonstrated that the products encoded in the HCV genome interfere with and disturb intracellular signal transduction, often by phosphorylation of cellular proteins. Moreover, some of the HCV-encoded proteins seem to serve as substrates for host cell protein kinases. These phosphorylations affect the biological functions of the antigens. In many cases it could be demonstrated that only short stretches of the linear sequence of the viral or cellular proteins are involved and play a crucial role for these phosphorylation events. The identification of these small polypeptide elements and the subsequent development of strategies to inhibit protein-protein interactions involving them may be the first step towards reducing the chronicity and/or of the carcinogenicity of the virus. This review summarizes current knowledge of intracellular phosphorylation processes that are affected by HCV.
Assuntos
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Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Hepacivirus Limite: Humans Idioma: En Revista: Arch Virol Ano de publicação: 2003 Tipo de documento: Article
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Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Hepacivirus Limite: Humans Idioma: En Revista: Arch Virol Ano de publicação: 2003 Tipo de documento: Article