[Clinical observation on the efficacy of ivermectin in the treatment of intestinal nematode infections].
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
; 21(2): 113-5, 2003.
Article
em Zh
| MEDLINE
| ID: mdl-12884628
ABSTRACT
OBJECTIVE:
To observe the efficacy and side effects of ivermectin in the treatment of intestinal nematode infections.METHODS:
A single dose of ivermectin 0.1, 0.2, 0.2 and 0.2 mg/kg was orally administered to cases with infection of Ascaris, hookworm, Trichuris and Enterobius respectively. A single dose of albendazole 400 mg was used as control.RESULTS:
The egg negative conversion rates of ivermectin and albendazole were both 100% (34/34) for Ascaris infection, 17.6% (6/34) and 76.5% (26/34) respectively for hookworm infection, 67.6% (23/34) and 47.1% (16/34) respectively for Trichuris infection, 58.8% (20/34) and 100% (34/34) respectively for Enterobius infection. The worm discharge reached a peak in 1-2 days after treatment. The side effect of ivermectin was mild and transient showing no adverse effect on blood picture, liver function, renal function or ECG.CONCLUSION:
Ivermectin shows similar effect on Ascaris with albendazole, better effect on Trichuris and poorer effect on hookworm and Enterobius than albendazole.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Ivermectina
/
Enteropatias Parasitárias
/
Infecções por Nematoides
/
Antinematódeos
Limite:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
/
Middle aged
Idioma:
Zh
Revista:
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi
Ano de publicação:
2003
Tipo de documento:
Article