Sulfa resistance and dihydropteroate synthase mutants in recurrent Pneumocystis carinii pneumonia.
Emerg Infect Dis
; 9(7): 864-7, 2003 Jul.
Article
em En
| MEDLINE
| ID: mdl-12890330
ABSTRACT
Failure of sulfa or sulfone prophylaxis is associated with mutations in Pneumocystis carinii gene coding for dihydropteroate synthase (DHPS). The DHPS genotype was analyzed in AIDS patients who had two separate episodes of P. carinii pneumonia. The results suggest that DHPS mutations can be selected de novo within patients by the pressure of a sulfa or sulfone drug.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pneumocystis
/
Pneumonia por Pneumocystis
/
Sulfonamidas
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Sulfonas
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Farmacorresistência Fúngica
/
Di-Hidropteroato Sintase
/
Mutação
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Emerg Infect Dis
Ano de publicação:
2003
Tipo de documento:
Article