Photochemical degradation of solid-state nisoldipine monitored by HPLC.
J Pharm Biomed Anal
; 32(4-5): 929-35, 2003 Aug 08.
Article
em En
| MEDLINE
| ID: mdl-12899979
ABSTRACT
The photochemical degradation of solid-state nisoldipine, 1,4-dihydropyridine calcium antagonist, was investigated under daylight and UV light conditions. Degradation products were identified by using the retention times of corresponding standards and quantified by high-performance liquid chromatographic method. The daylight illumination induced appearance of nitrosophenylpyridine, while formation of second degradation product, nitrophenylpyridine, was observed only upon UV light illumination. The photodegradation kinetics of solid-state nisoldipine under daylight and UV light illumination belongs to class of zero-order reactions. The rate constants of disappearance of nisoldipine upon illumination were determined for raw material as well as pharmaceuticals (tablets, film-tablets and capsules).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Nisoldipino
/
Tecnologia Farmacêutica
/
Luz
Idioma:
En
Revista:
J Pharm Biomed Anal
Ano de publicação:
2003
Tipo de documento:
Article