Synthesis of dendrimer-based biotin radiopharmaceuticals to enhance whole-body clearance.
Nucl Med Biol
; 30(6): 617-25, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-12900287
ABSTRACT
To synthesize a biotin radiopharmaceutical that clears rapidly, dendrimer was used as a carrier and conjugated with succinimidyl 3-[(125)I]iodobenzoate and tetrafluorophenyl norbiotinamidosuccinate. Then, succinic anhydride was used to reduce its pI. In mice, the non-succinylated product showed high liver (67% ID/g) and kidney (44% ID/g) uptakes and whole-body retention (94% ID) at 20 min that persisted for 12 hr. The corresponding organ uptakes (22% and 11% ID/g) and the whole-body retention (47% ID) were drastically reduced by succinylation (p<0.0001). Lysine co-injection further lowered renal uptake.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Biotina
/
Aminas
/
Iodobenzoatos
/
Marcação por Isótopo
/
Rim
/
Fígado
Limite:
Animals
Idioma:
En
Revista:
Nucl Med Biol
Ano de publicação:
2003
Tipo de documento:
Article