[Changes in the expression of cellular alpha and beta tubulins in patients with sporadic type colorectal cancer]. / Alterazione della espressione delle tubuline cellulari alfa e beta in pazienti affetti da cancro colorettale di tipo sporadico.
G Chir
; 24(5): 171-3, 2003 May.
Article
em It
| MEDLINE
| ID: mdl-12945166
ABSTRACT
The aim of this preliminar report is to evaluate alfa and beta tubulins, components of cellular microtubules, alterated expression in sporadic colorectal cancer patients. The Authors considered 16 patients who underwent surgery for sporadic colorectal carcinoma with radical intent. Alfa and beta tubulins were evaluated in tumoral mucosa by immunohistochemistry. In 56.2% of the examined patients a low expression of alfa and beta tubulins was showed while the alteration of alfa tubulin was showed in 81.2% of the patients. This finding supports the hypothesis of Porter that alterations in microtubule structure might be part of the cellular response to DNA damage.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
/
Neoplasias Colorretais
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
It
Revista:
G Chir
Ano de publicação:
2003
Tipo de documento:
Article