Lifestyle-related risk factors for Parkinson's disease: a population-based study.
Acta Neurol Scand
; 108(4): 239-44, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-12956856
ABSTRACT
OBJECTIVES:
To investigate the association of major lifestyle-related risk factors with the prevalent cases of Parkinson's disease (PD) identified by the Italian Longitudinal Study on Aging.METHODS:
A total of 5632 individuals randomly selected from the population registers of eight centers were screened for parkinsonism using both a questionnaire and a neurologic examination. Screened positives underwent a structured clinical work-up for the diagnosis of parkinsonism and parkinsonism subtypes.RESULTS:
We identified 113 prevalent cases of PD. Age, male gender, and pesticide-use license were significantly related to PD. Heavy smoking was inversely related to PD. Age (OR = 1.1; 95% CI, 1.06-1.15) and pesticide-use license (OR = 3.7; 95% CI, 1.6-8.6) kept their significant correlation with the disease in the multivariate analysis to adjust for all the variables under investigation. Multivariate analyses were made for men and women separately pesticide exposure was positively associated with PD only in men.CONCLUSIONS:
Pesticide exposure might represent a candidate for environmental factors involved in PD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Assunção de Riscos
/
Estilo de Vida
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2003
Tipo de documento:
Article