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Beta-endorphin and neurotensin in brainstem and cerebrospinal fluid in the sudden infant death syndrome.
Coquerel, A; Buser, M; Tayot, J; Pfaff, F; Matray, F; Proust, B.
Afiliação
  • Coquerel A; Centre Hospitalier Universitaire, Rouen, France.
Neurochem Int ; 20(1): 97-102, 1992 Jan.
Article em En | MEDLINE | ID: mdl-1304324
Beta-endorphin (BE) and neurotensin (NT) are two neuropeptides which induce apneas. In infants who died of Sudden Infant Death Syndrome (SIDS) we measured, in brainstem and CSF, BE and NT by IRMA and RIA respectively. BE and NT levels are compared to same aged infant and adult controls. CSF BE level was significantly higher in SIDS than in the two control groups (86 +/- 14 vs 33 +/- 13 and 16 +/- 5 pmol/l). In 6 SIDS victims NT and BE were assayed in 5 brainstem sections, each of them divided in median, intermediate and lateral parts. We found high levels of BE in every fragment (3-11 pmol/mg protein) while NT elevated values were restricted to the mesencephalic regions (1.4-12 pmol/mg), the medial pons (6 pmol/mg) and the intermediate parts of the medulla (including the olive: 1.3-1.6 pmol/mg). These results support the hypothesis that NT and/or BE could induce or participate to the fetal issue of SIDS.
Assuntos
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Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 7_ODS3_muertes_prevenibles_nacidos_ninos Base de dados: MEDLINE Assunto principal: Morte Súbita do Lactente / Tronco Encefálico / Neurotensina / Beta-Endorfina Limite: Adult / Humans / Infant Idioma: En Revista: Neurochem Int Ano de publicação: 1992 Tipo de documento: Article
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Coleções: 01-internacional Contexto em Saúde: 2_ODS3 / 7_ODS3_muertes_prevenibles_nacidos_ninos Base de dados: MEDLINE Assunto principal: Morte Súbita do Lactente / Tronco Encefálico / Neurotensina / Beta-Endorfina Limite: Adult / Humans / Infant Idioma: En Revista: Neurochem Int Ano de publicação: 1992 Tipo de documento: Article