Presence of insulin-like growth factor-I receptors and absence of growth hormone receptors in the antler tip.
Endocrinology
; 130(5): 2513-20, 1992 May.
Article
em En
| MEDLINE
| ID: mdl-1315246
ABSTRACT
Red deer antler tips in the growing phase were removed 60 days after the recommencement of growth for autoradiographical studies and RRAs. Sections were incubated with radiolabeled GH or insulin-like growth factor-I (IGF-I), with or without excess competing unlabeled hormones, and were analyzed autoradiographically. There was negligible binding of [125I]GH in any histological zone of antler sections. [125I]IGF-I showed highest specific binding in the chondroblast zone to a receptor demonstrating binding characteristics of the type 1 IGF receptor. The lowest specific binding of [125I]IGF-I was to prechondroblasts. RRAs on antler microsomal membrane preparations RRAs on antler microsomal membrane preparations confirmed the absence of GH receptors and the presence of type 1 IGF receptors found by autoradiography. These findings suggest that IGF-I may act in an endocrine manner in antler growth through a receptor resembling the type 1 IGF receptor. The presence of type 1 receptors in the chondroblast zone implicates IGF-I involvement in cartilage formation through matrixogenesis. There is no support for IGF-I having a major role in mitosis in the antler.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Chifres de Veado
/
Receptores da Somatotropina
/
Fator de Crescimento Insulin-Like I
/
Cervos
/
Receptores de Superfície Celular
Limite:
Animals
Idioma:
En
Revista:
Endocrinology
Ano de publicação:
1992
Tipo de documento:
Article