Exposure to acellular blood products and risk of HIV infection in hemophiliacs from Belo Horizonte, Brazil.
Rev Inst Med Trop Sao Paulo
; 34(3): 227-32, 1992.
Article
em En
| MEDLINE
| ID: mdl-1342075
ABSTRACT
Results of a HIV prevalence study conducted in hemophiliacs from Belo Horizonte, Brazil are presented. History of exposure to acellular blood components was determined for the five year period prior to entry in the study, which occurred during 1986 and 1987. Patients with coagulations disorders (hemophilia A = 132, hemophilia B = 16 and coagulation disorders other than hemophilia = 16) were transfused with liquid cryoprecipitate, locally produced, lyophilized cryoprecipitate, imported from São Paulo (Brazil) and factor VIII and IX, imported from Rio de Janeiro (Brazil), Europe, and United States. Thirty six (22%) tested HIV seropositive. The univariate and multivariate analysis (logistic model) demonstrated that the risk of HIV infection during the study period was associated with the total units of acellular blood components transfused. In addition, the proportional contribution of the individual components to the total acellular units transfused, namely a increase in factor VIII/IX and lyophilized cryoprecipitate proportions, were found to be associated with HIV seropositivity. This analysis suggest that not only the total amount of units was an important determinant of HIV infection, but that the risk was also associated with the specific component of blood transfused.
Palavras-chave
Americas; Biology; Blood Supply; Brazil; Developing Countries; Diseases; Equipment And Supplies; Examinations And Diagnoses; Hematological Effects; Hemic System; Hereditary Diseases; Hiv Infections; Hiv Serodiagnosis; Laboratory Examinations And Diagnoses; Latin America; Measurement; Physiology; Prevalence; Research Methodology; Research Report; Risk Factors; South America; Viral Diseases
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
População Urbana
/
Fator IX
/
Fator VIII
/
Infecções por HIV
/
HIV-1
/
Reação Transfusional
/
Hemofilia A
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Aspecto:
Determinantes_sociais_saude
Limite:
Adolescent
/
Adult
/
Humans
/
Male
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Rev Inst Med Trop Sao Paulo
Ano de publicação:
1992
Tipo de documento:
Article