Effects of interferon alpha on murine cytomegalovirus replication.
Microbiologica
; 15(2): 183-6, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1376391
ABSTRACT
The present study examined the protective effect of IFN-alpha against mouse cytomegalovirus (MCMV) infection in embryo fibroblasts (MEF) of genetically resistant (C3H/HeJ) and susceptible (C57BL/6) mouse strains. At a M.O.I. of 1 IFN-alpha was protective in C3H/HeJ-MEF but not in C57BL/6-MEF. Dot-blot analysis during MCMV replication in C3H/HeJ-MEF showed that IFN-alpha pretreatment reduced the steady state level of immediate early and late mRNAs but partially reduced early gene expression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Interferon-alfa
/
Citomegalovirus
Limite:
Animals
Idioma:
En
Revista:
Microbiologica
Ano de publicação:
1992
Tipo de documento:
Article