In vivo activity of novel sulphonic derivatives of distamycin A.
EXS
; 61: 459-62, 1992.
Article
em En
| MEDLINE
| ID: mdl-1377572
ABSTRACT
Solid tumor growth can be modulated through inhibition of vascularization elicited by angiogenic factors. With the objective to complex these factors, new derivatives of distamycin A were synthesized and evaluated in vitro [1] and in vivo for their ability, after i.v. administration, to inhibit bFGF-induced vascularization and the growth of M5076 murine reticulosarcoma implanted i.m. The tested compounds were able to block angiogenesis with inhibition values ranging between 70-100%. Moreover, they were found to be capable of inducing tumor inhibition with values ranging between 40% and 95% at non-toxic doses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfoma Difuso de Grandes Células B
/
Distamicinas
/
Neovascularização Patológica
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Revista:
EXS
Ano de publicação:
1992
Tipo de documento:
Article