Hydroxyurea induction of fetal hemoglobin synthesis in sickle-cell disease.
Semin Oncol
; 19(3 Suppl 9): 61-6, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1379374
ABSTRACT
In the past 8 years, it has become apparent that some cytotoxic drugs that interfere with DNA replication can reprogram erythroid progenitors to switch from adult hemoglobin to fetal hemoglobin (HbF) production. Hydroxyurea has now been shown to substantially increase HbF in patients with sickle cell anemia. Since HbF interferes with sickle hemoglobin polymerization, hydroxyurea may become an important therapeutic agent for patients with sickle cell anemia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hemoglobina Fetal
/
Hidroxiureia
/
Anemia Falciforme
Limite:
Humans
Idioma:
En
Revista:
Semin Oncol
Ano de publicação:
1992
Tipo de documento:
Article