[Studies on early stage changes of peroxide lipid in isoproterenol-induced myocardial injury].
Yakugaku Zasshi
; 112(8): 557-62, 1992 Aug.
Article
em Ja
| MEDLINE
| ID: mdl-1432604
ABSTRACT
The amount of peroxide lipid in vivo in the early stage of the experimental model of myocardial infarction in a rat induced by the administration of isoproterenol (Isp) was measured as the value of malonic dialdehyde (MDA). The model of myocardial infarction was made by giving 75 mg/kg of Isp to the rat weighing 270 +/- 10 g. After the administration of Isp, the amounts of lipid in the serum and in the myocardial tissue were measured, and a blood chemistry test (glutamic oxaloacetic dehydrogenase, glutamic pyruvic transaminase, lactate dehydrogenase, free fatty acid, creatine kinase) was simultaneously carried out on the serum. The value of the amount of peroxide lipid in the serum began to elevate 3 h after the administration of Isp and reached a maximum value at 6 h. The value of the amount of peroxide lipid in the tissue began to elevate 30 min after the administration and reached a maximum at 3 h. Each blood chemistry disclosed the elevation 30 min after the administration. As mentioned above, the production of peroxide lipid in vivo on the myocardial disorder in the early stage after the administration of Isp and the biochemical changes showed a significant correlation. From these results it is suggested that the myocardial disorder induced by the administration of Isp has already developed at 30 min after the administration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isoproterenol
/
Peróxidos Lipídicos
/
Infarto do Miocárdio
Limite:
Animals
Idioma:
Ja
Revista:
Yakugaku Zasshi
Ano de publicação:
1992
Tipo de documento:
Article