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Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability.
Borthwick, Alan D; Davies, Dave E; Ertl, Peter F; Exall, Anne M; Haley, Terry M; Hart, Graham J; Jackson, Deborah L; Parry, Nigel R; Patikis, Angela; Trivedi, Naimisha; Weingarten, Gordon G; Woolven, James M.
Afiliação
  • Borthwick AD; Department of Medicinal Chemistry CVU UK, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, United Kingdom. alan.d.borthwick@gsk.com
J Med Chem ; 46(21): 4428-49, 2003 Oct 09.
Article em En | MEDLINE | ID: mdl-14521407
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Pirróis / Serina Endopeptidases / Citomegalovirus / Lactamas Limite: Animals / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2003 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Inibidores de Proteases / Pirróis / Serina Endopeptidases / Citomegalovirus / Lactamas Limite: Animals / Humans Idioma: En Revista: J Med Chem Ano de publicação: 2003 Tipo de documento: Article