[Pharmacodynamics study on "tao hua zhi xie granule"].

ABSTRACT

The anthraco-propulsion and the drug induced mice diarrhea models were used to observe the intestine propulsion and the anti-diarrhea effect of "Tao Hua Zhi Xie Granule" (THZXG), and the anti-inflammation effect of THZXG was studied. The results showed that THZXG could obviously reduce the incidence and frequency of the mice diarrhea induced by Folium Sennae and castor-oil, and propelling movement of mice small intestine after hypodermic injection of neostigmine. The actions were acted in a dose-dependent manner. 11.70 and 17.55 mg/kg THZXG(ig) could also inhibit the increased permeability of intraperitoneal capillary induced by acetic acid in mice.