Mechanisms of pathogenicity of influenza A (H5N1) viruses in mice.
Avian Dis
; 47(3 Suppl): 1131-4, 2003.
Article
em En
| MEDLINE
| ID: mdl-14575128
ABSTRACT
Avian-like H5N1 influenza viruses isolated from humans in 1997 were shown to have two distinct pathogenic phenotypes in BALB/c mice, after intranasal inoculation and without prior adaptation to this host. To further understand the mechanisms of H5N1 pathogenicity, we investigated the consequences of the mute of viral inoculation on morbidity and mortality, viral replication in pulmonary and systemic organs, and lymphocyte depletion. This study demonstrates the importance of extrapulmonary spread and replication, particularly in the brain, for the lethality of H5N1 viruses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Orthomyxoviridae
/
Influenza Humana
/
Virus da Influenza A Subtipo H5N1
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Avian Dis
Ano de publicação:
2003
Tipo de documento:
Article