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Tibolone and risk of endometrial polyps: a prospective, comparative study with hormone therapy.
Perez-Medina, Tirso; Bajo-Arenas, José; Haya, Javier; Sanfrutos, Luis; Iniesta, Silvia; Bueno, Beatriz; Castelo-Branco, Camil.
Afiliação
  • Perez-Medina T; Santa Cristina University Hospital, Universidad Autónoma de Madrid, Madrid, Spain. tperezm@meditex.es
Menopause ; 10(6): 534-7, 2003.
Article em En | MEDLINE | ID: mdl-14627862
OBJECTIVE: To assess the incidence of endometrial polyps during postmenopausal replacement therapy with tibolone, using an appropriate control group. DESIGN: A total of 485 postmenopausal women were included in this open, prospective, comparative study for a duration of 36 months. Of this group, 249 women received 2.5 mg/day of tibolone and 244 women served as controls, receiving continuous-combined estrogen-progestogen therapy (HT). Transvaginal ultrasound, hysteroscopy, and directed biopsies were performed before treatment was initiated and at the end of the study. RESULTS: Two hundred twenty-one of the women receiving tibolone and 203 receiving continuous-combined HT completed the study. Endometrial polyps were detected in 74 women (33.4%) from the tibolone group and in 22 women (10.8%) from the HT group (P < 0.01). The vaginal bleeding rate did not differ between the groups. The frequency of atrophic polyps was significantly higher in the tibolone group (P < 0.01). No difference was found in the size of the polyps. CONCLUSIONS: Tibolone increases by threefold the risk for endometrial polyps.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pólipos / Terapia de Reposição de Estrogênios / Moduladores de Receptor Estrogênico / Hiperplasia Endometrial / Norpregnenos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Menopause Ano de publicação: 2003 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pólipos / Terapia de Reposição de Estrogênios / Moduladores de Receptor Estrogênico / Hiperplasia Endometrial / Norpregnenos Tipo de estudo: Etiology_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Middle aged Idioma: En Revista: Menopause Ano de publicação: 2003 Tipo de documento: Article