Structural genomics efforts at the Chinese Academy of Sciences and Peking University.
J Struct Funct Genomics
; 4(2-3): 137-9, 2003.
Article
em En
| MEDLINE
| ID: mdl-14649298
ABSTRACT
Structural genomics efforts at the Chinese Academy of Sciences and Peking University are reported in this article. The major targets for the structural genomics project are targeted proteins expressed in human hematopoietic stem/progenitor cells, proteins related to blood diseases and other human proteins. Up to now 328 target genes have been constructed in expression vectors. Among them, more than 50% genes have been expressed in Escherichia coli, approximately 25% of the resulting proteins are soluble, and 35 proteins have been purified. Crystallization, data collection and structure determination are continuing. Experiences accumulated during this initial stage are useful for designing and applying high-throughput approaches in structural genomics.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Bases de Dados Factuais
/
Clonagem Molecular
/
Genômica
País/Região como assunto:
Asia
Idioma:
En
Revista:
J Struct Funct Genomics
Ano de publicação:
2003
Tipo de documento:
Article