Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
Mol Cell Neurosci
; 24(3): 538-54, 2003 Nov.
Article
em En
| MEDLINE
| ID: mdl-14664806
ABSTRACT
Transcriptional activation is a key link between neuronal activity and long-term synaptic plasticity. Little is known about genes responding to this activation whose products directly effect functional and structural changes at the synapse. cpg15 is an activity-regulated gene encoding a membrane-bound ligand that regulates dendritic and axonal arbor growth and synaptic maturation. We report that cpg15 is an immediate-early gene induced by Ca(2+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. Activity-dependent cpg15 expression requires convergent activation of the CaM kinase and MAP kinase pathways. Although activation of PKA is not required for activity-dependent expression, cpg15 is induced by cAMP in active neurons. CREB binds the cpg15 promoter in vivo and partially regulates its activity-dependent expression. cpg15 is an effector gene that is a target for signal transduction pathways that mediate synaptic plasticity and thus may take part in an activity-regulated transcriptional program that directs long-term changes in synaptic connections.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Transcricional
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Regulação da Expressão Gênica
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Terminações Pré-Sinápticas
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Transmissão Sináptica
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Proteínas de Membrana
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Proteínas do Tecido Nervoso
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Revista:
Mol Cell Neurosci
Ano de publicação:
2003
Tipo de documento:
Article