Reduced short-term obsessive-compulsive symptoms in schizophrenic patients treated with risperidone: a single-blind prospective study.
Hum Psychopharmacol
; 18(8): 635-40, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14696023
ABSTRACT
BACKGROUND:
Risperidone is a widely used agent as first-line treatment in schizophrenia with a favorable side-effect profile. However, a number of case reports have suggested an increase in obsessive-compulsive symptoms in patients treated with risperidone.OBJECTIVE:
The aim of this study was to investigate the effect of risperidone on obsessive-compulsive symptoms in the treatment of schizophrenia.METHOD:
Forty patients with DSM-IV diagnosis of schizophrenia were included in the study. The Yale-Brown obsessive compulsive scale was administered before, at the end of first and second months of treatment. Paired-samples t-test was used to compare the three assessments.RESULTS:
There was not an increase, but a significant decrease, in YBOCS scores over time during risperidone treatment (p<0.05).CONCLUSION:
In the present study risperidone caused a significant decrease in obsessive-compulsive symptoms in the treatment of schizophrenia.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Antipsicóticos
/
Risperidona
/
Transtorno Obsessivo-Compulsivo
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Hum Psychopharmacol
Ano de publicação:
2003
Tipo de documento:
Article