Modeling of human monoamine oxidase A: from low resolution threading models to accurate comparative models based on crystal structures.
Neurotoxicology
; 25(1-2): 47-61, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14697880
ABSTRACT
The recently published crystal structure of monoamine oxidase (MAO) B was a major breakthrough for structural and functional understanding of flavin containing amine oxidases it opens a new era of research and provides new opportunities to those interested in the biochemistry and pharmacology of those important drug targets. In particular, it allowed accurate modeling of human MAO A, both proteins sharing over 70% sequence identity. In the present contribution, we summarize the efforts made in order to obtain structural information on the human MAO A, including sequence analysis, secondary structure predictions, and preliminary models obtained by fold recognition and comparative modeling based on proteins sharing low sequence identity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
/
Modelos Químicos
/
Monoaminoxidase
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Neurotoxicology
Ano de publicação:
2004
Tipo de documento:
Article