Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.
Bioorg Med Chem Lett
; 14(2): 343-6, 2004 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-14698155
ABSTRACT
New indeno[1,2-c]pyrazol-4-one cyclin dependent kinase inhibitors have been disclosed. The most promising compounds are nanomolar enzyme inhibitors with excellent activity against tumor cells. The most advanced compound retains cell culture activity even in the presence of human serum proteins. The most advanced compound did not kill the normal fibroblast line AG1523.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
Quinases Ciclina-Dependentes
/
Inibidores Enzimáticos
/
Compostos Heterocíclicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2004
Tipo de documento:
Article