Plasma glutathione level in paracetamol daily abuser patients. Changes in plasma cysteine and thiol groups after reduced glutathione administration.
Toxicol Lett
; 64-65 Spec No: 757-61, 1992 Dec.
Article
em En
| MEDLINE
| ID: mdl-1471232
ABSTRACT
Since plasma reduced glutathione (GSH) seems to reflect liver GSH content, we have assessed plasma GSH in patients using paracetamol daily. In these patients a significant lower plasma GSH concentration was found with respect to controls. After the i.v. administration of GSH free plasma cysteine was 12 fold higher than in basal condition and all the pattern of plasma thiol groups was modified. This work suggests that the possible protective effect of GSH administration is due to the availability of plasma thiol compounds that enter the cell rather than GSH itself.
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Coleções:
01-internacional
Contexto em Saúde:
2_ODS3
Base de dados:
MEDLINE
Assunto principal:
Compostos de Sulfidrila
/
Transtornos Relacionados ao Uso de Substâncias
/
Cisteína
/
Glutationa
/
Acetaminofen
Limite:
Humans
Idioma:
En
Revista:
Toxicol Lett
Ano de publicação:
1992
Tipo de documento:
Article