Milnacipran: a comparative analysis of human monoamine uptake and transporter binding affinity.
Biol Psychiatry
; 55(3): 320-2, 2004 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-14744476
ABSTRACT
BACKGROUND:
Though selective serotonin reuptake inhibitors have revolutionized the field of psychiatry with demonstrated efficacy in affective and anxiety disorders with minimal side effects, norepinephrine-serotonin reuptake inhibitors may provide efficacy similar to tricyclic antidepressants without the adverse side effects associated with tricyclic antidepressants.METHODS:
The affinity and selectivity of milnacipran, duloxetine, venlafaxine, citalopram, amitriptyline, and nortriptyline were determined for the human serotonin, norepinephrine, and dopamine transporters.RESULTS:
Both milnacipran and duloxetine were potent inhibitors of serotonin and norepinephrine uptake. Unlike duloxetine and venlafaxine, milnacipran appears serotonin transporter selective in binding (ratio = 2.61) and norepinephrine transporter selective in uptake (ratio =.45).CONCLUSIONS:
Milnacipran's binding and uptake inhibition profile more closely resembles that of the tricyclic antidepressants than that of duloxetine. Whether these differences observed in vitro manifest themselves in vivo is not clear.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Glicoproteínas de Membrana
/
Proteínas de Transporte
/
Inibidores Seletivos de Recaptação de Serotonina
/
Inibidores da Captação Adrenérgica
/
Ciclopropanos
/
Simportadores
/
Proteínas do Tecido Nervoso
/
Neurônios
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Biol Psychiatry
Ano de publicação:
2004
Tipo de documento:
Article