B cell receptor signal strength determines B cell fate.
Nat Immunol
; 5(3): 317-27, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-14758357
ABSTRACT
B cell receptor (BCR)-mediated antigen recognition is thought to regulate B cell differentiation. BCR signal strength may also influence B cell fate decisions. Here, we used the Epstein-Barr virus protein LMP2A as a constitutively active BCR surrogate to study the contribution of BCR signal strength in B cell differentiation. Mice carrying a targeted replacement of Igh by LMP2A leading to high or low expression of the LMP2A protein developed B-1 or follicular and marginal zone B cells, respectively. These data indicate that BCR signal strength, rather than antigen specificity, determines mature B cell fate. Furthermore, spontaneous germinal centers developed in gut-associated lymphoid tissue of LMP2A mice, indicating that microbial antigens can promote germinal centers independently of BCR-mediated antigen recognition.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores de Antígenos de Linfócitos B
/
Transdução de Sinais
/
Centro Germinativo
Limite:
Animals
Idioma:
En
Revista:
Nat Immunol
Ano de publicação:
2004
Tipo de documento:
Article