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[Efficacy of a daily application of mesalazine (Pentasa) suppository with progressive release, in the treatment of ulcerative proctitis. A double-blind versus placebo randomized trial]. / Efficacité d'une application quotidienne d'un suppositoire de mésalazine (Pentasa) à libération progressive, dans le traitement des poussées de rectite ulcéro-hémorragique. Essai randomisé en double aveugle contre placebo.
Ngô, Y; Gélinet, J M; Ivanovic, A; Kac, J; Schénowitz, G; Vilotte, J; Rambaud, J C.
Afiliação
  • Ngô Y; Service de Gastroentérologie, Hôpital Saint-Lazare, Paris.
Gastroenterol Clin Biol ; 16(10): 782-6, 1992.
Article em Fr | MEDLINE | ID: mdl-1478406
Therapeutic efficacy of mesalazine controlled-release suppository 1 g once daily was compared with that of a placebo during 2 weeks in 50 patients (26 in the mesalazine group, 24 in the placebo group) with ulcerative proctitis, in a double-blind randomized trial. Endoscopic and clinical remission was seen in 69 and 65% of mesalazine-treated patients and in 33 and 25% of placebo-treated patients respectively (P < or = 0.01). No side effects were seen. It is concluded that a once-a-day administration of 1 g mesalazine controlled-release suppository is effective for topical treatment of patients with ulcerative proctitis.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Ácidos Aminossalicílicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: Fr Revista: Gastroenterol Clin Biol Ano de publicação: 1992 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Ácidos Aminossalicílicos Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: Fr Revista: Gastroenterol Clin Biol Ano de publicação: 1992 Tipo de documento: Article