Antibacterial and antifungal agents. XV. Synthesis and antifungal activity of structural analogues of bifonazole and ketoconazole.
Arch Pharm (Weinheim)
; 325(11): 687-94, 1992 Nov.
Article
em En
| MEDLINE
| ID: mdl-1485835
ABSTRACT
The synthesis and antifungal activities of the cis- and trans-1-acetyl-4-[4-[[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethy l)- 1,3-dioxolan-4-yl]-methoxy]phenyl)piperazines 3 and 4 are reported. Stereochemical assignments to diastereomeric pairs of cis/trans isomers were made on the basis of 1H- and 13C-NMR data. Among test derivatives the best activity was shown by the benzoyl esters of the cis- and trans-[2-(1,1'-biphenyl-4-yl)-2-(1H-imidazol-1-ylmethyl)-1,3-di oxolan-4- yl]methanols 9 and 10.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imidazóis
/
Cetoconazol
/
Antifúngicos
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Ano de publicação:
1992
Tipo de documento:
Article