Antiviral activity of caspase inhibitors: effect on picornaviral 2A proteinase.
FEBS Lett
; 560(1-3): 51-5, 2004 Feb 27.
Article
em En
| MEDLINE
| ID: mdl-14987997
ABSTRACT
Peptide-based fluoromethyl ketones have been considered for many years to be highly specific caspase inhibitors distinctly blocking the progress of apoptosis in a variety of systems. Here we demonstrate that these compounds can significantly reduce rhinovirus multiplication in cell culture. In their methylated forms they block eIF4GI cleavage in vivo and in vitro and inhibit the activity of picornaviral 2A proteinases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Endopeptidases
/
Rhinovirus
/
Infecções por Picornaviridae
/
Inibidores de Caspase
Limite:
Humans
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2004
Tipo de documento:
Article