[Ocular involvement in Behçet's disease: first 5-year-results for visual development after treatment with interferon alfa-2a]. / Augenbeteiligung bei Morbus Behçet: Erste 5-Jahres-Ergebnisse zur Visusentwicklung nach Therapie mit Interferon alfa-2a.
Ophthalmologe
; 101(2): 129-34, 2004 Feb.
Article
em De
| MEDLINE
| ID: mdl-14991308
ABSTRACT
BACKGROUND:
Behçet's disease (BD) is a systemic vasculitis of unknown origin. Up to now ocular involvement has a poor visual prognosis irrespective of immunosuppressive treatment. Now recent open studies have shown that interferon alfa-2a (IFN alfa-2a) is very effective in the treatment of ocular BD. The purpose of this study was to evaluate the long-term development of visual acuity (VA) in patients with severe ocular BD who were treated with IFN alfa-2a.METHODS:
We included 15 eyes of 9 patients with an active panuveitis and/or retinal vasculitis due to BD refractory to immunosuppressive treatment. VA before initiation of IFN-therapy was compared to VA at the end of the follow-up time.RESULTS:
Mean follow-up time was 68.8+/-10.6 months. Mean duration of IFN-treatment was 40.6+/-17.0 months. With the exception of one patient IFN alfa-2a could be discontinued in complete remission of ocular symptoms. During the follow-up time 10 eyes showed an increase of VA of two lines or more. In 5 eyes VA remained stable. There was no decrease of VA in any eye. If a macular edema was present, a quick response to IFN alfa-2a was seen. No eye developed a pale optic disk during follow-up.CONCLUSION:
Compared to conventional immunosuppressants, interferon alfa-2a seems to be much more effective to prevent a loss or decrease of VA over a long period of time in patients with severe ocular BD.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pan-Uveíte
/
Síndrome de Behçet
/
Interferon-alfa
/
Vasculite Retiniana
/
Imunossupressores
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
De
Revista:
Ophthalmologe
Ano de publicação:
2004
Tipo de documento:
Article