Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis.
Bioorg Med Chem Lett
; 14(7): 1717-20, 2004 Apr 05.
Article
em En
| MEDLINE
| ID: mdl-15026057
ABSTRACT
Potent small molecule biaryl diketopiperazine FSH receptor agonists such as 10c (EC(50)=13 nM) and 11f (EC(50)=1.2 nM) were discovered through the design, synthesis and evaluation of three biaryl diketopiperazine optimization libraries with over 300 compounds. These libraries were prepared via solid-phase parallel synthesis using a cyclization-release method.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Receptores do FSH
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2004
Tipo de documento:
Article