Screening of antibacterial extracts from plants native to the Brazilian Amazon Rain Forest and Atlantic Forest.
Braz J Med Biol Res
; 37(3): 379-84, 2004 Mar.
Article
em En
| MEDLINE
| ID: mdl-15060707
ABSTRACT
More than 20% of the world's biodiversity is located in Brazilian forests and only a few plant extracts have been evaluated for potential antibacterial activity. In the present study, 705 organic and aqueous extracts of plants obtained from different Amazon Rain Forest and Atlantic Forest plants were screened for antibacterial activity at 100 microg/ml, using a microdilution broth assay against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa and Escherichia coli. One extract, VO581, was active against S. aureus (minimum inhibitory concentration (MIC)=140 microg/ml and minimal bactericidal concentration (MBC)=160 microg/ml, organic extract obtained from stems) and two extracts were active against E. faecalis, SM053 (MIC=80 microg/ml and MBC=90 microg/ml, organic extract obtained from aerial parts), and MY841 (MIC=30 microg/ml and MBC=50 microg/ml, organic extract obtained from stems). The most active fractions are being fractionated to identify their active substances. Higher concentrations of other extracts are currently being evaluated against the same microorganisms.
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Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Bactérias Gram-Negativas
/
Bactérias Gram-Positivas
/
Antibacterianos
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Braz J Med Biol Res
Ano de publicação:
2004
Tipo de documento:
Article