Novel CCR1 antagonists with improved metabolic stability.

Brown, Matthew F; Avery, Mike; Brissette, William H; Chang, J H; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P; Gladue, Ronald P; Kath, John C; Krueger, Suzanne S; Lira, Paul D; Lillie, Brett M; Lundquist, Greg D; Mairs, Erin N; McElroy, Eric B; McGlynn, Molly A; Paradis, Timothy J; Poss, Christopher S; Rossulek, Michelle I; Shepard, Richard M; Sims, Jeff; Strelevitz, Timothy J; Truesdell, Susan; Tylaska, Laurie A; Yoon, Kwansik; Zheng, Deye

Brown, Matthew F; Avery, Mike; Brissette, William H; Chang, J H; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P; Gladue, Ronald P; Kath, John C; Krueger, Suzanne S; Lira, Paul D; Lillie, Brett M; Lundquist, Greg D; Mairs, Erin N; McElroy, Eric B; McGlynn, Molly A; Paradis, Timothy J; Poss, Christopher S; Rossulek, Michelle I; Shepard, Richard M; Sims, Jeff; Strelevitz, Timothy J; Truesdell, Susan; Tylaska, Laurie A; Yoon, Kwansik; Zheng, Deye.

Afiliação

Brown MF; Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA. matthew_f_brown@groton.pfizer.com

Bioorg Med Chem Lett ; 14(9): 2175-9, 2004 May 03.

Article em En | MEDLINE | ID: mdl-15081003

ABSTRACT

ABSTRACT

The synthesis, biological activity, and pharmacokinetic profile of novel CCR1 antagonists are described.

Assuntos

Receptores de Quimiocinas/antagonistas & inibidores; Animais; Cães; Haplorrinos; Farmacocinética; Receptores CCR1

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Quimiocinas Limite: Animals Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2004 Tipo de documento: Article

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